City, already missing six first-team players, saw defender Manuel Akanji sidelined with a calf injury during the warm-up.
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Forward Savinho was later stretchered off in the 63rd minute after what appeared to be an ankle injury.
Guardiola also noted that defender Ruben Dias, who was subbed off at half-time, is “struggling” at times.
“We have 13 players, we are in real difficulties,” Guardiola said.
“The guys that play, they finish most of them with problems and we’ll see how they recover.
“I think we are in trouble, because in nine years we’ve never been in the situation with so many injuries.
“The players make a step forward, more together than ever, and we will try to do this week in this short time of recovery.”
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