The two players struggled to make impact in Friday’s 4-4 home draw against same opponent at the Samuel Ogbemudia Stadium, Benin City.
Okoye conceded four times, while Akpoguma, who played as right-back also put up a poor performance in the game.
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According to reports, Kaizer Chiefs goalkeeper Daniel Akpeyi will take the place of Okoye, while the trio of Ola Aina, Chidozie Awaziem and Tyronne Ebuehi are in line to replace Akpoguma.
The Super Eagles top Group L with seven points from three games.
The West Africans could a seal a place in Cameroon 2022 with a win against the Leone Stars at the Siaka Stevens Stadium, Freetown.
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