Eko Hot Blog reports that the blaze broke out at the Grand Diamond City hotel-casino in the border town of Poipet at around 23:30 (16:30 GMT) on Wednesday.
Around 400 people were inside the building when it caught fire, police said.
Video circulating on social media shows what appeared to be people jumping or falling from upper floors.
Many Thai nationals were in the hotel, which backs onto the border, local media reports.
Authorities are still working to determine the cause of the fire.
Some of the injured were transferred to hospitals in Thailand’s Sa Kaeo province, a Thai foreign ministry official told the AFP news agency.
Poipet is a key crossing point between the two countries. It is also popular for its casinos, which many Thai nationals visit because gambling is mostly illegal in Thailand.
Source: BBC
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