The 20-year-old, who played the full 90 minutes in United’s 0-0 draw against Aston Villa on Sunday while wearing a brace on his left knee, has been replaced in the Argentina squad by Leicester City’s Facundo Buonanotte.
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The world champions currently lead the South American qualifying standings, sitting two points ahead of second-placed Colombia.
Under Lionel Scaloni, Argentina will face sixth-placed Venezuela on Thursday and host eighth-placed Bolivia next Tuesday.
Garnacho has earned seven caps for his country and played a significant role in helping Argentina secure a record 16th Copa America title this summer.
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